LeHavreV1, France, Analysis, bibRecord, 000170

Health-related quality-of-life in patients with newly diagnosed multiple myeloma in the FIRST trial: lenalidomide plus low-dose dexamethasone versus melphalan, prednisone, thalidomide

Identifieur interne : 000170 ( France/Analysis ); précédent : 000169; suivant : 000171

Health-related quality-of-life in patients with newly diagnosed multiple myeloma in the FIRST trial: lenalidomide plus low-dose dexamethasone versus melphalan, prednisone, thalidomide

Auteurs : Michel Delforge [Belgique] ; Leonard Minuk [Canada] ; Jean-Claude Eisenmann [France] ; Bertrand Arnulf [France] ; Letizia Canepa [Italie] ; Alberto Fragasso [Italie] ; Serge Leyvraz [Suisse] ; Christian Langer [Allemagne] ; Yousef Ezaydi [Royaume-Uni] ; Dan T. Vogl [États-Unis] ; Pilar Giraldo-Castellano [Espagne] ; Sung-Soo Yoon [Corée du Sud] ; Charles Zarnitsky [France] ; Martine Escoffre-Barbe [France] ; Bernard Lemieux [Canada] ; Kevin Song [Canada] ; Nizar Jacques Bahlis [Canada] ; Shien Guo [États-Unis] ; Mara Silva Monzini [États-Unis] ; Annette Ervin-Haynes [États-Unis] ; Vanessa Houck [États-Unis] ; Thierry Facon [France]

Source :

Haematologica [ 0390-6078 ] ; 2015.

RBID : PMC:4450629

English descriptors

KwdEn :
- Aged, Aged, 80 and over, Antineoplastic Combined Chemotherapy Protocols (administration & dosage), Cross-Sectional Studies, Dexamethasone (administration & dosage), Female, Health Status, Humans, Male, Melphalan (administration & dosage), Multiple Myeloma (diagnosis), Multiple Myeloma (drug therapy), Multiple Myeloma (psychology), Prednisone (administration & dosage), Quality of Life (psychology), Thalidomide (administration & dosage), Thalidomide (analogs & derivatives).
MESH :
- chemical , administration & dosage : Dexamethasone, Melphalan, Prednisone, Thalidomide.
- administration & dosage : Antineoplastic Combined Chemotherapy Protocols.
- chemical , analogs & derivatives : Thalidomide.
- diagnosis : Multiple Myeloma.
- drug therapy : Multiple Myeloma.
- psychology : Multiple Myeloma, Quality of Life.
- Aged, Aged, 80 and over, Cross-Sectional Studies, Female, Health Status, Humans, Male.
mix :
- 80 and over, Aged, Antineoplastic Combined Chemotherapy Protocols, Cross-Sectional Studies, Dexamethasone, Female, Health Status, Humans, Male, Melphalan, Multiple Myeloma, Prednisone, Quality of Life, Thalidomide, Aged.

Abstract

We compared the health-related quality-of-life of patients with newly diagnosed multiple myeloma aged over 65 years or transplant-ineligible in the pivotal, phase III FIRST trial. Patients received: i) continuous lenalidomide and low-dose dexamethasone until disease progression; ii) fixed cycles of lenalidomide and low-dose dexamethasone for 18 months; or iii) fixed cycles of melphalan, prednisone, thalidomide for 18 months. Data were collected using the validated questionnaires (QLQ-MY20, QLQ-C30, and EQ-5D). The analysis focused on the EQ-5D utility value and six domains pre-selected for their perceived clinical relevance. Lenalidomide and low-dose dexamethasone, and melphalan, prednisone, thalidomide improved patients’ health-related quality-of-life from baseline over the duration of the study across all pre-selected domains of the QLQ-C30 and EQ-5D. In the QLQ-MY20, lenalidomide and low-dose dexamethasone demonstrated a significantly greater reduction in the Disease Symptoms domain compared with melphalan, prednisone, thalidomide at Month 3, and significantly lower scores for QLQ-MY20 Side Effects of Treatment at all post-baseline assessments except Month 18. Linear mixed-model repeated-measures analyses confirmed the results observed in the cross-sectional analysis. Continuous lenalidomide and low-dose dexamethasone delays disease progression versus melphalan, prednisone, thalidomide and has been associated with a clinically meaningful improvement in health-related quality-of-life. These results further establish continuous lenalidomide and low-dose dexamethasone as a new standard of care for initial therapy of myeloma by demonstrating superior health-related quality-of-life during treatment, compared with melphalan, prednisone, thalidomide.

Url:

DOI: 10.3324/haematol.2014.120121
PubMed: 25769541
PubMed Central: 4450629

Affiliations:

Allemagne, Belgique, Canada, Corée du Sud, Espagne, France, Italie, Royaume-Uni, Suisse, États-Unis
Alberta, Bade-Wurtemberg, Canton de Vaud, District de Tübingen, Massachusetts, New Jersey, Pennsylvanie
Calgary, Lausanne, Le Havre, Lille, Mulhouse, Paris, Rennes, Ulm
Université de Calgary

Links to Exploration step

PMC:4450629

Le document en format XML

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<author><name sortKey="Ezaydi, Yousef" sort="Ezaydi, Yousef" uniqKey="Ezaydi Y" first="Yousef" last="Ezaydi">Yousef Ezaydi</name>
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<author><name sortKey="Vogl, Dan T" sort="Vogl, Dan T" uniqKey="Vogl D" first="Dan T." last="Vogl">Dan T. Vogl</name>
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<author><name sortKey="Giraldo Castellano, Pilar" sort="Giraldo Castellano, Pilar" uniqKey="Giraldo Castellano P" first="Pilar" last="Giraldo-Castellano">Pilar Giraldo-Castellano</name>
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<author><name sortKey="Yoon, Sung Soo" sort="Yoon, Sung Soo" uniqKey="Yoon S" first="Sung-Soo" last="Yoon">Sung-Soo Yoon</name>
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<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Seoul National University Hospital</wicri:regionArea>
</affiliation>
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<author><name sortKey="Zarnitsky, Charles" sort="Zarnitsky, Charles" uniqKey="Zarnitsky C" first="Charles" last="Zarnitsky">Charles Zarnitsky</name>
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<author><name sortKey="Escoffre Barbe, Martine" sort="Escoffre Barbe, Martine" uniqKey="Escoffre Barbe M" first="Martine" last="Escoffre-Barbe">Martine Escoffre-Barbe</name>
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<author><name sortKey="Lemieux, Bernard" sort="Lemieux, Bernard" uniqKey="Lemieux B" first="Bernard" last="Lemieux">Bernard Lemieux</name>
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<author><name sortKey="Song, Kevin" sort="Song, Kevin" uniqKey="Song K" first="Kevin" last="Song">Kevin Song</name>
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<wicri:regionArea>Vancouver General Hospital, Vancouver, BC</wicri:regionArea>
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<author><name sortKey="Bahlis, Nizar Jacques" sort="Bahlis, Nizar Jacques" uniqKey="Bahlis N" first="Nizar Jacques" last="Bahlis">Nizar Jacques Bahlis</name>
<affiliation wicri:level="4"><nlm:aff id="af17-1000826">Tom Baker Cancer Centre – University of Calgary, Calgary, AL, Canada</nlm:aff>
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<author><name sortKey="Guo, Shien" sort="Guo, Shien" uniqKey="Guo S" first="Shien" last="Guo">Shien Guo</name>
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<author><name sortKey="Monzini, Mara Silva" sort="Monzini, Mara Silva" uniqKey="Monzini M" first="Mara Silva" last="Monzini">Mara Silva Monzini</name>
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<author><name sortKey="Facon, Thierry" sort="Facon, Thierry" uniqKey="Facon T" first="Thierry" last="Facon">Thierry Facon</name>
<affiliation wicri:level="1"><nlm:aff id="af20-1000826">Hôpital Claude Huriez, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Health-related quality-of-life in patients with newly diagnosed multiple myeloma in the FIRST trial: lenalidomide plus low-dose dexamethasone versus melphalan, prednisone, thalidomide</title>
<author><name sortKey="Delforge, Michel" sort="Delforge, Michel" uniqKey="Delforge M" first="Michel" last="Delforge">Michel Delforge</name>
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<author><name sortKey="Eisenmann, Jean Claude" sort="Eisenmann, Jean Claude" uniqKey="Eisenmann J" first="Jean-Claude" last="Eisenmann">Jean-Claude Eisenmann</name>
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<author><name sortKey="Canepa, Letizia" sort="Canepa, Letizia" uniqKey="Canepa L" first="Letizia" last="Canepa">Letizia Canepa</name>
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<author><name sortKey="Fragasso, Alberto" sort="Fragasso, Alberto" uniqKey="Fragasso A" first="Alberto" last="Fragasso">Alberto Fragasso</name>
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<country xml:lang="fr">Italie</country>
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<author><name sortKey="Leyvraz, Serge" sort="Leyvraz, Serge" uniqKey="Leyvraz S" first="Serge" last="Leyvraz">Serge Leyvraz</name>
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<author><name sortKey="Langer, Christian" sort="Langer, Christian" uniqKey="Langer C" first="Christian" last="Langer">Christian Langer</name>
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<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Klinik für Innere Medizin III, Ulm</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Ulm</settlement>
</placeName>
</affiliation>
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<author><name sortKey="Ezaydi, Yousef" sort="Ezaydi, Yousef" uniqKey="Ezaydi Y" first="Yousef" last="Ezaydi">Yousef Ezaydi</name>
<affiliation wicri:level="1"><nlm:aff id="af9-1000826">Royal Hallamshire Hospital, Sheffield, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Royal Hallamshire Hospital, Sheffield</wicri:regionArea>
<wicri:noRegion>Sheffield</wicri:noRegion>
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<author><name sortKey="Vogl, Dan T" sort="Vogl, Dan T" uniqKey="Vogl D" first="Dan T." last="Vogl">Dan T. Vogl</name>
<affiliation wicri:level="2"><nlm:aff id="af10-1000826">Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Giraldo Castellano, Pilar" sort="Giraldo Castellano, Pilar" uniqKey="Giraldo Castellano P" first="Pilar" last="Giraldo-Castellano">Pilar Giraldo-Castellano</name>
<affiliation wicri:level="1"><nlm:aff id="af11-1000826">CIBER Enfermedades Raras (CIBERER), Translational Research Unit, Miguel Servet University Hospital, Zaragoza, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>CIBER Enfermedades Raras (CIBERER), Translational Research Unit, Miguel Servet University Hospital, Zaragoza</wicri:regionArea>
<wicri:noRegion>Zaragoza</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yoon, Sung Soo" sort="Yoon, Sung Soo" uniqKey="Yoon S" first="Sung-Soo" last="Yoon">Sung-Soo Yoon</name>
<affiliation wicri:level="1"><nlm:aff id="af12-1000826">Seoul National University Hospital, Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
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</author>
<author><name sortKey="Zarnitsky, Charles" sort="Zarnitsky, Charles" uniqKey="Zarnitsky C" first="Charles" last="Zarnitsky">Charles Zarnitsky</name>
<affiliation wicri:level="1"><nlm:aff id="af13-1000826">Rhumatologie Nord, Hôpital J. Monod, Le Havre, France</nlm:aff>
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<placeName><settlement type="city">Le Havre</settlement>
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</author>
<author><name sortKey="Escoffre Barbe, Martine" sort="Escoffre Barbe, Martine" uniqKey="Escoffre Barbe M" first="Martine" last="Escoffre-Barbe">Martine Escoffre-Barbe</name>
<affiliation wicri:level="1"><nlm:aff id="af14-1000826">CHRU Hôpital de Pontchaillou, Rennes, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>CHRU Hôpital de Pontchaillou, Rennes</wicri:regionArea>
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</author>
<author><name sortKey="Lemieux, Bernard" sort="Lemieux, Bernard" uniqKey="Lemieux B" first="Bernard" last="Lemieux">Bernard Lemieux</name>
<affiliation wicri:level="1"><nlm:aff id="af15-1000826">CHUM Hôpital Notre-Dame, Montreal, QUE, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>CHUM Hôpital Notre-Dame, Montreal, QUE</wicri:regionArea>
<wicri:noRegion>QUE</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Song, Kevin" sort="Song, Kevin" uniqKey="Song K" first="Kevin" last="Song">Kevin Song</name>
<affiliation wicri:level="1"><nlm:aff id="af16-1000826">Vancouver General Hospital, Vancouver, BC, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Vancouver General Hospital, Vancouver, BC</wicri:regionArea>
<wicri:noRegion>BC</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bahlis, Nizar Jacques" sort="Bahlis, Nizar Jacques" uniqKey="Bahlis N" first="Nizar Jacques" last="Bahlis">Nizar Jacques Bahlis</name>
<affiliation wicri:level="4"><nlm:aff id="af17-1000826">Tom Baker Cancer Centre – University of Calgary, Calgary, AL, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Tom Baker Cancer Centre – University of Calgary, Calgary, AL</wicri:regionArea>
<orgName type="university">Université de Calgary</orgName>
<placeName><settlement type="city">Calgary</settlement>
<region type="state">Alberta</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Guo, Shien" sort="Guo, Shien" uniqKey="Guo S" first="Shien" last="Guo">Shien Guo</name>
<affiliation wicri:level="2"><nlm:aff id="af18-1000826">Evidera, Lexington, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Evidera, Lexington, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Monzini, Mara Silva" sort="Monzini, Mara Silva" uniqKey="Monzini M" first="Mara Silva" last="Monzini">Mara Silva Monzini</name>
<affiliation wicri:level="2"><nlm:aff id="af19-1000826">Celgene Corporation, Summit, NJ, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Celgene Corporation, Summit, NJ</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ervin Haynes, Annette" sort="Ervin Haynes, Annette" uniqKey="Ervin Haynes A" first="Annette" last="Ervin-Haynes">Annette Ervin-Haynes</name>
<affiliation wicri:level="2"><nlm:aff id="af19-1000826">Celgene Corporation, Summit, NJ, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Celgene Corporation, Summit, NJ</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Houck, Vanessa" sort="Houck, Vanessa" uniqKey="Houck V" first="Vanessa" last="Houck">Vanessa Houck</name>
<affiliation wicri:level="2"><nlm:aff id="af19-1000826">Celgene Corporation, Summit, NJ, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Celgene Corporation, Summit, NJ</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Facon, Thierry" sort="Facon, Thierry" uniqKey="Facon T" first="Thierry" last="Facon">Thierry Facon</name>
<affiliation wicri:level="1"><nlm:aff id="af20-1000826">Hôpital Claude Huriez, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Hôpital Claude Huriez, Lille</wicri:regionArea>
<placeName><settlement type="city">Lille</settlement>
</placeName>
</affiliation>
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<series><title level="j">Haematologica</title>
<idno type="ISSN">0390-6078</idno>
<idno type="eISSN">1592-8721</idno>
<imprint><date when="2015">2015</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Antineoplastic Combined Chemotherapy Protocols (administration & dosage)</term>
<term>Cross-Sectional Studies</term>
<term>Dexamethasone (administration & dosage)</term>
<term>Female</term>
<term>Health Status</term>
<term>Humans</term>
<term>Male</term>
<term>Melphalan (administration & dosage)</term>
<term>Multiple Myeloma (diagnosis)</term>
<term>Multiple Myeloma (drug therapy)</term>
<term>Multiple Myeloma (psychology)</term>
<term>Prednisone (administration & dosage)</term>
<term>Quality of Life (psychology)</term>
<term>Thalidomide (administration & dosage)</term>
<term>Thalidomide (analogs & derivatives)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Dexamethasone</term>
<term>Melphalan</term>
<term>Prednisone</term>
<term>Thalidomide</term>
</keywords>
<keywords scheme="MESH" qualifier="administration & dosage" xml:lang="en"><term>Antineoplastic Combined Chemotherapy Protocols</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Thalidomide</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Multiple Myeloma</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Multiple Myeloma</term>
</keywords>
<keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Multiple Myeloma</term>
<term>Quality of Life</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Cross-Sectional Studies</term>
<term>Female</term>
<term>Health Status</term>
<term>Humans</term>
<term>Male</term>
</keywords>
<keywords scheme="mix" xml:lang="en"><term> 80 and over</term>
<term> Aged</term>
<term> Antineoplastic Combined Chemotherapy Protocols</term>
<term> Cross-Sectional Studies</term>
<term> Dexamethasone</term>
<term> Female</term>
<term> Health Status</term>
<term> Humans</term>
<term> Male</term>
<term> Melphalan</term>
<term> Multiple Myeloma</term>
<term> Prednisone</term>
<term> Quality of Life</term>
<term> Thalidomide</term>
<term>Aged</term>
</keywords>
</textClass>
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</teiHeader>
<front><div type="abstract" xml:lang="en"><p>We compared the health-related quality-of-life of patients with newly diagnosed multiple myeloma aged over 65 years or transplant-ineligible in the pivotal, phase III FIRST trial. Patients received: i) continuous lenalidomide and low-dose dexamethasone until disease progression; ii) fixed cycles of lenalidomide and low-dose dexamethasone for 18 months; or iii) fixed cycles of melphalan, prednisone, thalidomide for 18 months. Data were collected using the validated questionnaires (QLQ-MY20, QLQ-C30, and EQ-5D). The analysis focused on the EQ-5D utility value and six domains pre-selected for their perceived clinical relevance. Lenalidomide and low-dose dexamethasone, and melphalan, prednisone, thalidomide improved patients’ health-related quality-of-life from baseline over the duration of the study across all pre-selected domains of the QLQ-C30 and EQ-5D. In the QLQ-MY20, lenalidomide and low-dose dexamethasone demonstrated a significantly greater reduction in the Disease Symptoms domain compared with melphalan, prednisone, thalidomide at Month 3, and significantly lower scores for QLQ-MY20 Side Effects of Treatment at all post-baseline assessments except Month 18. Linear mixed-model repeated-measures analyses confirmed the results observed in the cross-sectional analysis. Continuous lenalidomide and low-dose dexamethasone delays disease progression <italic>versus</italic>
 melphalan, prednisone, thalidomide and has been associated with a clinically meaningful improvement in health-related quality-of-life. These results further establish continuous lenalidomide and low-dose dexamethasone as a new standard of care for initial therapy of myeloma by demonstrating superior health-related quality-of-life during treatment, compared with melphalan, prednisone, thalidomide.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Belgique</li>
<li>Canada</li>
<li>Corée du Sud</li>
<li>Espagne</li>
<li>France</li>
<li>Italie</li>
<li>Royaume-Uni</li>
<li>Suisse</li>
<li>États-Unis</li>
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<region><li>Alberta</li>
<li>Bade-Wurtemberg</li>
<li>Canton de Vaud</li>
<li>District de Tübingen</li>
<li>Massachusetts</li>
<li>New Jersey</li>
<li>Pennsylvanie</li>
</region>
<settlement><li>Calgary</li>
<li>Lausanne</li>
<li>Le Havre</li>
<li>Lille</li>
<li>Mulhouse</li>
<li>Paris</li>
<li>Rennes</li>
<li>Ulm</li>
</settlement>
<orgName><li>Université de Calgary</li>
</orgName>
</list>
<tree><country name="Belgique"><noRegion><name sortKey="Delforge, Michel" sort="Delforge, Michel" uniqKey="Delforge M" first="Michel" last="Delforge">Michel Delforge</name>
</noRegion>
</country>
<country name="Canada"><noRegion><name sortKey="Minuk, Leonard" sort="Minuk, Leonard" uniqKey="Minuk L" first="Leonard" last="Minuk">Leonard Minuk</name>
</noRegion>
<name sortKey="Bahlis, Nizar Jacques" sort="Bahlis, Nizar Jacques" uniqKey="Bahlis N" first="Nizar Jacques" last="Bahlis">Nizar Jacques Bahlis</name>
<name sortKey="Lemieux, Bernard" sort="Lemieux, Bernard" uniqKey="Lemieux B" first="Bernard" last="Lemieux">Bernard Lemieux</name>
<name sortKey="Song, Kevin" sort="Song, Kevin" uniqKey="Song K" first="Kevin" last="Song">Kevin Song</name>
</country>
<country name="France"><noRegion><name sortKey="Eisenmann, Jean Claude" sort="Eisenmann, Jean Claude" uniqKey="Eisenmann J" first="Jean-Claude" last="Eisenmann">Jean-Claude Eisenmann</name>
</noRegion>
<name sortKey="Arnulf, Bertrand" sort="Arnulf, Bertrand" uniqKey="Arnulf B" first="Bertrand" last="Arnulf">Bertrand Arnulf</name>
<name sortKey="Escoffre Barbe, Martine" sort="Escoffre Barbe, Martine" uniqKey="Escoffre Barbe M" first="Martine" last="Escoffre-Barbe">Martine Escoffre-Barbe</name>
<name sortKey="Facon, Thierry" sort="Facon, Thierry" uniqKey="Facon T" first="Thierry" last="Facon">Thierry Facon</name>
<name sortKey="Zarnitsky, Charles" sort="Zarnitsky, Charles" uniqKey="Zarnitsky C" first="Charles" last="Zarnitsky">Charles Zarnitsky</name>
</country>
<country name="Italie"><noRegion><name sortKey="Canepa, Letizia" sort="Canepa, Letizia" uniqKey="Canepa L" first="Letizia" last="Canepa">Letizia Canepa</name>
</noRegion>
<name sortKey="Fragasso, Alberto" sort="Fragasso, Alberto" uniqKey="Fragasso A" first="Alberto" last="Fragasso">Alberto Fragasso</name>
</country>
<country name="Suisse"><region name="Canton de Vaud"><name sortKey="Leyvraz, Serge" sort="Leyvraz, Serge" uniqKey="Leyvraz S" first="Serge" last="Leyvraz">Serge Leyvraz</name>
</region>
</country>
<country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Langer, Christian" sort="Langer, Christian" uniqKey="Langer C" first="Christian" last="Langer">Christian Langer</name>
</region>
</country>
<country name="Royaume-Uni"><noRegion><name sortKey="Ezaydi, Yousef" sort="Ezaydi, Yousef" uniqKey="Ezaydi Y" first="Yousef" last="Ezaydi">Yousef Ezaydi</name>
</noRegion>
</country>
<country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Vogl, Dan T" sort="Vogl, Dan T" uniqKey="Vogl D" first="Dan T." last="Vogl">Dan T. Vogl</name>
</region>
<name sortKey="Ervin Haynes, Annette" sort="Ervin Haynes, Annette" uniqKey="Ervin Haynes A" first="Annette" last="Ervin-Haynes">Annette Ervin-Haynes</name>
<name sortKey="Guo, Shien" sort="Guo, Shien" uniqKey="Guo S" first="Shien" last="Guo">Shien Guo</name>
<name sortKey="Houck, Vanessa" sort="Houck, Vanessa" uniqKey="Houck V" first="Vanessa" last="Houck">Vanessa Houck</name>
<name sortKey="Monzini, Mara Silva" sort="Monzini, Mara Silva" uniqKey="Monzini M" first="Mara Silva" last="Monzini">Mara Silva Monzini</name>
</country>
<country name="Espagne"><noRegion><name sortKey="Giraldo Castellano, Pilar" sort="Giraldo Castellano, Pilar" uniqKey="Giraldo Castellano P" first="Pilar" last="Giraldo-Castellano">Pilar Giraldo-Castellano</name>
</noRegion>
</country>
<country name="Corée du Sud"><noRegion><name sortKey="Yoon, Sung Soo" sort="Yoon, Sung Soo" uniqKey="Yoon S" first="Sung-Soo" last="Yoon">Sung-Soo Yoon</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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Health-related quality-of-life in patients with newly diagnosed multiple myeloma in the FIRST trial: lenalidomide plus low-dose dexamethasone versus melphalan, prednisone, thalidomide

Health-related quality-of-life in patients with newly diagnosed multiple myeloma in the FIRST trial: lenalidomide plus low-dose dexamethasone versus melphalan, prednisone, thalidomide

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